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Α-Methyl-5-HT: Wikis


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Systematic (IUPAC) name
CAS number 304-52-9
ATC code  ?
PubChem 2107
Chemical data
Formula C 11H14N2O 
Mol. mass 190.242 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

α-Methyl-5-hydroxytryptamine (α-Methyl-5-HT) is a tryptamine derivative closely related to the neurotransmitter serotonin. It acts as a moderately selective full agonist at the 5-HT2 receptors, having the highest affinity for 5-HT2B and the lowest for 5-HT2A.[1][2][3]

See also


  1. ^ Ismaiel AM, Titeler M, Miller KJ, Smith TS, Glennon RA. 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin. Journal of Medicinal Chemistry. 1990 Feb;33(2):755-8. PMID 2299641
  2. ^ Edwards E, Ashby CR Jr, Wang RY. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21. PMID 1407401
  3. ^ Baxter G, Kennett G, Blaney F, Blackburn T. 5-HT2 receptor subtypes: a family re-united? Trends in Pharmacological Sciences. 1995 Mar;16(3):105-10. PMID 7792930


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