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Α-bungarotoxin: Wikis

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Schematic diagram of the three-dimensional structure of α-bungarotoxin. Disulfide bonds shown in gold. From PDB 1IDI.

α-bungarotoxin is one of the components of the venom of the elapid snake Taiwanese banded krait (Bungarus multicinctus). It binds irreversibly and competitively to the acetylcholine receptor found at the neuromuscular junction, causing paralysis, respiratory failure and death in the victim.

α-bungarotoxin is also a selective antagonist of the α7 nicotinic acetylcholine receptor in the brain, and as such has applications in neuroscience research.

History

Bungarotoxin was discovered by Chuan-Chiung Chang and Chen-Yuan Lee of the National Taiwan University in 1963.[1][2]

References

  1. ^ Chang C (1999). "Looking back on the discovery of alpha-bungarotoxin". J. Biomed. Sci. 6 (6): 368–75. PMID 10545772.  
  2. ^ Chu N (2005). "Contribution of a snake venom toxin to myasthenia gravis: the discovery of alpha-bungarotoxin in Taiwan". Journal of the history of the neurosciences 14 (2): 138–48. doi:10.1080/096470490881770. PMID 16019658. http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ProduktNr=224178&Ausgabe=226136&ArtikelNr=25412&filename=25412.pdf.  

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