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1-(2-Pyrimidinyl)piperazine: Wikis


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IUPAC name
CAS number 20980-22-7
Molecular formula C8H12N4
Molar mass 164.21 g mol−1
Density 1.158 g/mL
Boiling point

277 °C, 550 K, 531 °F

R-phrases R36/37/38
S-phrases S26 S36
Flash point 110 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

1-(2-Pyrimidinyl)piperazine (1-PP) is a psychoactive drug and research chemical of the piperazine and azapirone chemical classes. It acts as an α2-adrenergic receptor antagonist,[2] and as a 5-HT1A receptor partial agonist to a much lesser extent.[3] It is not known to have any significant affinity for the D2 receptor. 1-PP is a common metabolite of buspirone, gepirone, ipsapirone, and tandospirone, but not alnespirone, and likely contributes to their side effect profiles.[2][4]


  1. ^ 1-(2-Pyrimidyl)piperazine at Sigma-Aldrich
  2. ^ a b Blier; Curet, O; Chaput, Y; De Montigny, C (1991). "Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--II. Effects of acute administration of 1-PP and long-term administration of tandospirone on noradrenergic neurotransmission". Neuropharmacology 30 (7): 691–701. doi:10.1016/0028-3908(91)90176-C. PMID 1681447.   edit
  3. ^ Zuideveld, K. P.; Rusic-pavletic, J.; Maas, H. J.; Peletier, L. A.; Van Der Graaf, P. H.; Danhof, M. (2002). "Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats". The Journal of pharmacology and experimental therapeutics 303 (3): 1130–1137. doi:10.1124/jpet.102.036798. PMID 12438536.   edit
  4. ^ Astier; Lambás Señas, L; Soulière, F; Schmitt, P; Urbain, N; Rentero, N; Bert, L; Denoroy, L et al. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity". European journal of pharmacology 459 (1): 17–26. doi:10.1016/S0014-2999(02)02814-5. PMID 12505530.   edit


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