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More info on 2-Butyl-3-(p-tolyl)quinuclidine

2-Butyl-3-(p-tolyl)quinuclidine: Wikis

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Butyltolylquinuclidine
Systematic (IUPAC) name
(2R,3S,4S)-2-butyl-3-p-tolylquinuclidine
Identifiers
CAS number  ?
ATC code  ?
PubChem 9903250
Chemical data
Formula C 18H27N 
Mol. mass 257.414 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal
Routes  ?

2-Butyl-3-(p-tolyl)quinuclidine (BTQ) is a stimulant DRI.[1] It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse,[2] and produces similar effects to cocaine in animal studies, although milder and longer lasting.

References

  1. ^ Sakamuri, S; Enyedy; Zaman; Tella; Kozikowski; Flippen-Anderson; Farkas; Johnson et al. (2003). "2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors". Bioorganic & medicinal chemistry 11 (6): 1123–36. doi:10.1016/S0968-0896(02)00450-9. PMID 12614900.   edit
  2. ^ Enyedy, IJ; Sakamuri; Zaman; Johnson; Wang (2003). "Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors". Bioorganic & medicinal chemistry letters 13 (3): 513–7. doi:10.1016/S0960-894X(02)00943-5. PMID 12565962.   edit
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