Domain (2002) and Resurrection (2000) by author Steve Alten: A fictional series that tells the events of the Gabriel twins after discovering the mystery behind 2012.
2012: The War for Souls by author Whitley Strieber (2007) is a novel about three parallel earths and the occurrences leading up to December 21, 2012 in each as the walls between them begin to thin and allow passage through gateways to the others. A film adaptation is proposed, produced by Michael Bay.
Absconders (2009) by Karen Haynes depicts the perilous journey of survivors of increasingly catastrophic events (global warming sets the stage, solar flares cause elecromagnetic storms, climate changes result, and astronomical events mark the passage of time toward the Earth's inevitable rendezvous with the Dark Rift in the center of our galaxy) of the year 2012, where each character's actions have a direct bearing on the outcome of their encounters in a not-too-distant future.
The Crimson Purging by Jonathan Kaelin is a 2008 science fiction novel involving the governments of the world uniting to maintain the secrets of what really will happen in 2012.
2012: The end of the world? (Original Title: 2012: La fine del mondo?) (2009) by Roberto Giacobbo states many theories about what could happen to the world in 2012. Also analyses many different outcomes of that possible future.
Time Storm 2012: Atlantis and the Mayan Prophecy (2009) by Author Juliann Farnsworth. An epic science fiction adventure. While doing research on the magnetic anomalies of the Bermuda Triangle, Dr. Mark Turner, uncovers the secrets of the Mayan Calendar doomsday predictions.
PW2 2012: The End of the Beginning (2009) by M.C.Miller. A bizarre apocalyptic spectacle. As the world faces an increasing pattern of strange days, Hamilton Ray struggles with a wild theory about a cosmic Probability Wave and a 13.7 billion year countdown that's about to end. Humanity reacts to the unthinkable that something fundamental is changing with the universe. There's a distinct probability that something is different – about probability.
The Civilization Loop: The End is the Beginning (2007) by Jason R. Thrift. A science fiction novel where a researcher, Dr. Robert "Bobby" Peterson, unlocks the secret to time travel. Due to a "time shift" from traveling back and forth to the past, a paradox ensues wherein the Earth of current day, May 5, 2012, is destroyed. By a twist of fate, the researchers journey back to 10,000 B.C. where they establish the civilization of Atlantis and hide clues throughout history to warn the future of the impending doom.
In the Courts of the Sun (2009) by Brian D'Amato. A modern Maya scientist goes back in time to discover why the ancient kings forecast the end of the world in 2012.
Jojo's Bizarre Adventure by Hirohiko Araki: In the 6th part of this manga, the protagonists Jolyne Kujo, Hermes, Emporio, Anasui and Weather Report have to stop the villain Enrico Pucci from erasing the universe. Pucci obtains the stand Stairway to Heaven, which has the power of rewriting the universe, and tries to use the stand to create the perfect world for his master Dio. All these events occur in 2012, with the current universe ending near the completion of the thirteenth cycle of the Mayan calendar.
"A Certain Shade of Green," a song from the Incubus album S.C.I.E.N.C.E., references 2012 in the following lines: Are you gonna stand around till 2012 A.D.? / What are you waiting for, a certain shade of green?. December 21, 2012 also appears to be the date when the video for Incubus's song "Warning" is supposed to take place.
Genesis's song "Get'em Out By Friday" from their 1972 album Foxtrot, sets "18/9/2012" (on the printed operistic-dialog lyrics) as the date when "Genetic Control" would set a height restriction on human beings so that twice as many people could fit on real estate properties.
The Hed PE song "I.F.O." (to be found on their self-titled album), which is about UFO sightings and governmental conspiracies to cover them up, references the year 2012: "Prepare to meet your maker in the skies over the pyramids / Check Stonehenge / Go ask the Mayans / 2012 soon come / I will be waitin' sayin' I told you so / When the skies are ripped open / And the mothership lands on your cynical ass".
The song "2012 — Demise of the 5th Sun" by the melodic death metal band Scar Symmetry is a reference to the year 2012. "For the lines on the fractal wave / Fit the course of history / They're created to work as one till the end / When the winter solstice comes / Actualizing the prophecy / The demise in 2012 realized"
The Testament song "3 Days in Darkness", off of The Gathering album is a song about 2012, and speaks of the earth being swallowed in molten fire.
VNV Nation's album Praise the Fallen" has the subtitle "PTF 2012", which is also the name of a track in the album, which seems to be predominantly about an upcoming war. The song, "Honour" starts with the line, "Passive fields, January 2012..."
Heavy metal band Burnt By The Sun's two albums both deal with prophecies concerning the year 2012.
"2012" is the name of the 2005 album by the experimental rock band Old Time Relijun, and several songs make references to ancient Mayan culture, such as "Burial Mound" and "The King of Lost Light."
On the band Hella's album There's No 666 in Outer Space there is a track called "2012 and Countless" in which the only words are "There's no 666 in Outer Space" repeated.
Metal band Ewigkeit's album Radio Ixtlan has a track entitled "Live at Palenque 2012" referencing both the Mayan calendar date and the site at which the Temple of Inscriptions where it is carved.
Canibus mentions the year 2012 and December 21, 2012 on his Poet Laureate Infinity vocals and on his 2007 album For Whom the Beat Tolls.
One of the puzzles later on in La Mulana (A freeware PC game based on many of the older MSX games released) states you need to 'walk the end year of the Aztec's Fifth Age.' The player must then light only the torches of the gates that correspond to the numbers in the year '2012'.
The game Persona 4 ends in the year 2012 no matter which story ending you get.
In the game Assassin's Creed and Assassin's Creed II, Desmond Miles is being held captive by a group of mysterious scientists in the year 2012 leading to a large conspiracy about an event happening on 12/21/2012. Many of the writings of blood on the wall in the first game hint at this by giving a code 21122012
The game Oni briefly mentions a series of 'Freedom Riots' that occurred in 2012.
According to the front cover of the game, Road Trip Adventure is set in September of this year.