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3,4-Dihydroxystyrene: Wikis


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3,4-Dihydroxystyrene
Systematic (IUPAC) name
4-vinylbenzene-1,2-diol
Identifiers
CAS number 6053-02-7
ATC code  ?
PubChem 151398
ChemSpider 133430
Chemical data
Formula C8H8O2
Mol. mass 136.15 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.

See also

References

  1. ^ Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica Et Biophysica Acta 789 (2): 111–8. PMID 6148105. http://linkinghub.elsevier.com/retrieve/pii/0167-4838(84)90194-8.  







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