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3-Iodothyronamine: Wikis

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3-Iodothyronamine
3-Iodothyronamine.svg
IUPAC name
Other names T1AM
Identifiers
CAS number 712349-95-6
SMILES
Properties
Molecular formula C14H14INO2
Molar mass 355.17 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

3-iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor.[1][2] When injected into rodents, T1AM causes a rapid drop in body temperature and alterations in blood pressure and heart rate.[3]

T1AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output.[4]

See also

External links

References

  1. ^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). "3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone". Nat. Med. 10 (6): 638–42. doi:10.1038/nm1051. PMID 15146179.  
  2. ^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). "Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues". J. Med. Chem. 49 (3): 1101–12. doi:10.1021/jm0505718. PMID 16451074.  
  3. ^ "New compound may act to keep thyroid activity in check". http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php. Retrieved 2008-05-30.  
  4. ^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. PMID 17284482.  
Thyroid hormone metabolic intermediates
Tyrosine / iodotyrosine
Thyronine / iodothyronine
Thyronamine / iodothyronamine
3-Iodothyronamine · 3,3',5-Triiodothyronamine
see also enzymes







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