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3-hydroxybutyrate dehydrogenase: Wikis


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3-hydroxybutyrate dehydrogenase
EC number
CAS number 9028-38-0
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology AmiGO / EGO

In enzymology, a 3-hydroxybutyrate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxybutanoate + NAD+ \rightleftharpoons acetoacetate + NADH + H+

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD+, whereas its 3 products are acetoacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD+ oxidoreductase. Other names in common use include NAD+-beta-hydroxybutyrate dehydrogenase, hydroxybutyrate oxidoreductase, beta-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, 3-D-hydroxybutyrate dehydrogenase, and beta-hydroxybutyric dehydrogenase. This enzyme participates in synthesis and degradation of ketone bodies and butanoate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.

See also


  • Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH (1967). "Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides". Biochem. J. 102: 423–31. PMID 4291491. 
  • Delafield FP, Cooksey KE, Doudoroff M (1965). "beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei". J. Biol. Chem. 240: 4023–8. PMID 4954074. 
  • Lehninger AL, Sudduth HC and Wise JB (1960). "D-beta-Hydroxybutyric dehydrogenase of mitochondria". J. Biol. Chem. 235: 2450–2455. 


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