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Events

By place

Persian Empire

• The king of Caria, Pixodarus, dies and is succeeded by his son-in-law, Orontobates.
• As the Persian satraps have gathered for a war council at Zeleia, Memnon argues that it is preferable for the Persians to avoid a pitched battle and adopt a scorched earth tactic. Arsites, the satrap of Hellespontine Phrygia, will not allow his land to be burned and agrees with other satraps to reject this cautious advice.

Macedonia

• King Alexander III of Macedonia crosses the Dardanelles, leaving Antipater, who has already faithfully served his father, Philip II, as his deputy in Greece with over 13,000 men. Alexander himself commands about 30,000 foot soldiers and over 5,000 cavalry, of whom nearly 14,000 are Macedonians and about 7,000 are allies sent by the Greek League.
• May – Alexander wins a major victory against the Persians commanded by the Greek mercenary Memnon of Rhodes, in the Battle of the Granicus near the Sea of Marmara. A large number of King Darius III's Greek mercenaries are massacred, but 2,000 survivors are sent back to Macedonia in chains.
• Alexander accepts the surrender of the Persian provincial capital of Sardis (and its treasury) and proceeds down the Ionian coast.
• At Halicarnassus, Alexander successfully undertakes the first of many sieges, eventually forcing his opponents, the mercenary captain Memnon of Rhodes and the Persian satrap of Caria, Orontobates, to withdraw by sea. Alexander leaves Caria in the hands of Ada, who was the ruler of Caria before being deposed by her brother-in-law, Pixodarus.
• Alexander's victory exposes western Asia Minor to the Macedonians, and most of the cities in the region hasten to open their gates. The Ionian city of Miletus defies Alexander and he has to subdue it through a siege.

Italy

• Alexander of Epirus, at the request of colony of Taras (Tarentum) crosses over into Italy, to aid them against the Lucanians and Bruttii. He wins victories over the Italian Samnite tribes.

China

• The rulers of Wei and Qi agree to recognize each other as kings, formalizing the independence of the Warring States and the powerlessness of the Zhou Dynasty.

Births

• Zeno of Citium, Greek philosopher and the father of Stoicism

Deaths

• Pixodarus, King of Caria