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4-Acetoxy-DET: Wikis

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Systematic (IUPAC) name
3-(2-Diethylamino-ethyl)-1H-indol-4-yl acetate
CAS number  ?
ATC code  ?
PubChem  ?
ChemSpider 21106239
Chemical data
Formula C 16H22N2O2  
Mol. mass 273.36 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

4-Acetoxy-DET (4-Acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin or 4-AcO-DET is a hallucinogenic tryptamine. It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.[1]

It is expected that the compound is quickly hydrolyzed into the free phenol 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.



4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours.[2] The free base is also active when smoked in a dose range of 5–20 mg.[1] Smoking 4-acetoxy-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.


4-Acetoxy-DET is unscheduled in the United States, but possession and sales of 4-Acetoxy-DET could be prosecuted under the Federal Analog Act because of its structural similarities to DET.


  1. ^ a b Erowid 4-Acetoxy-DET Vaults : Primer. Accessed on April 19, 2007.
  2. ^ Tikhal: The Chemistry Continues by Alexander and Ann Shulgin. #16. 4-HO-DET. Accessed on April 19, 2007.

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