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2,5-Dimethoxy-4-chloroamphetamine
Systematic (IUPAC) name
1-(4-chloro-2,5-dimethoxy-phenyl)propan-2-amine
Identifiers
CAS number 123431-31-2
ATC code  ?
PubChem 542036
ChemSpider 472008
Chemical data
Formula C11H16ClNO2
Mol. mass 229.70 g/mol
SMILES eMolecules & PubChem
Synonyms 2,5-dimethoxy-4-chloroamphetamine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Unscheduled (AU) Schedule III (CA) Class A (UK) ? (US)
Routes  ?

2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was presumably first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved).[1]

Contents

Chemistry

DOC is a substituted alpha-methylated phenethylamine, a class of compounds commonly known as amphetamines. The phenethylamine equivalent (lacking the alpha-methyl group) is 2C-C. DOC has a stereocenter and R-(-)-DOC is the more active stereoisomer.

Pharmacology

DOC acts as a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated via its actions on the 5-HT2A receptor.

Dosage

DOC on blotter from Concord, CA.

A normal average dose of DOC ranges from 1 mg-5 mg[2 ] the former producing threshold effects, and the latter producing extremely strong effects. Doses up to 10 mg have been known to send the user into a restless stupor. Onset of the drug is 1-3 hours, peak and plateau at 4-8 hours, and a gradual come down. After effects can last well into the next day[2 ] [3]

Effects

Unlike simple amphetamines, DOC is a psychedelic that resembles DOB, mescaline, and other hallucinogens like LSD.These effects include open and closed eye visuals, increased awareness of sound and movement, and euphoria. Its properties as an amphetamine are dwarfed by its unmistakable and potent properties as strong and sometimes rough acting compound, with effects likened to 2C-B, high-dose LSD, or DOM. In PiHKAL, Shulgin describes it as an archetypal psychedelic (#64); its full-range visual, audio, physical and mental effects share some of the exhilarating clarity of high-dose LSD, and some of the overwhelming, humbling and "composting"/interweaving effect of high-dose mescaline. It is often praised in particular, apart from its longevity and potency, for its typical sense of calm and relative ease, making the duration noticeably more "doable" than the similar sort of ride 2C-B, for instance, involves.

Dangers

The toxicity of DOC is not known, but nausea, chest pains, and vasoconstriction have been reported by some users. In June 2006 four teenagers were admitted to a hospital in Metropolitan Detroit, Michigan after accidentally overdosing DOC.[1] To date, there have been no deaths attributed to DOC.

Popularity

Although rare on the black market, sales of DOC on blotting paper and in capsules was reported in late 2005 and again in late 2007. According to the DEA December Microgram, the Concord Police Department in Contra Costa County, California, in the US, seized "a small piece of crudely lined white blotter paper without any design, suspected LSD 'blotter acid'". They added "Unusually, the paper appeared to be hand-lined using two pens, in squares measuring approximately 6 x 6 millimeters. The paper displayed fluorescence when irradiated at 365 nanometers; however, color testing for LSD with para-dimethylaminobenzaldehyde (PDMAB) was negative. Analysis of a methanol extract by GC/MS indicated not LSD but rather DOC (not quantitated but a high loading based on the TIC)". DOC is sometimes misrepresented as LSD by unscrupulous dealers. This is particularly dangerous, as DOC is not known to have the safety profile of LSD. It can be particularly unsafe, in comparison to LSD, for those suffering from hypertension, as phenethylamine compounds (including analogues of DOC) are known to cause sharp increases in systolic blood pressure.

Legality

DOC is unscheduled in the United States. The Department of Justice considers it to be an analogue of DOB[4] and, as such, sales for human consumption or possession with the intent to ingest could be prosecuted under the Federal Analogue Act[5 ]. In the United States, the analogues DMA, DOB, and DOM are Schedule I controlled substances. DOC is scheduled in many other countries including Canada[5 ], Australia[5 ], Germany[5 ], New Zealand[5 ], United Kingdom[5 ], Sweden and Norway.

See also

References

External links








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