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4-Dimethylaminophenol: Wikis

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4-Dimethylaminophenol
4-Dimethylaminophenol.svg
Identifiers
CAS number 619-60-3
PubChem 22174
SMILES
InChI
InChI key JVVRCYWZTJLJSG-UHFFFAOYAU
ChemSpider ID 20816
Properties
Molecular formula C8H11NO
Molar mass 137.179 g/mol
Boiling point

165 °C (0.040 bar)

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1]

It works by generating methemoglobin. [2]

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.[3]

See also

References

  1. ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. PMID 11121929. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=2000&volume=55&issue=12&spage=1189.  
  2. ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097.  
  3. ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842.  
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