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5-Carboxamidotryptamine
Systematic (IUPAC) name
3-(2-aminoethyl)-1H-indole-5-carboxamide
Identifiers
CAS number 74885-09-9
ATC code  ?
PubChem 1809
Chemical data
Formula C 11H13N3O 
Mol. mass 203.240 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative and psychoactive drug closely related to the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It acts as a non-selective high affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity.[1][2] [3] 5-CT has negligible affinity for the 5-HT1E and 5-HT1F receptors.[4] 5-CT binds strongest to the 5-HT1A receptor and it was once thought to be selective for this site.[5][6]

See also

References

  1. ^ Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). "Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.". Eur J Pharmacol. 359 (1): 81–86. PMID 9831297.  
  2. ^ Wright CE, Angus JA. 5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets. Journal of Cardiovascular Pharmacology. 1989 Apr;13(4):557-64. PMID 2470992
  3. ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. http://www.acnp.org/g4/GN401000039/Ch039.html. Retrieved 2008-04-11.  
  4. ^ Stanton JA, Middlemiss DN, Beer MS. (1996). "Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.". Neuropharmacology. 35 (2): 223–229. PMID 8734492.  
  5. ^ Thomas DR, Middlemiss DN, Taylor SG, Nelson P, Brown AM. 5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors. British Journal of Pharmacology. 1999 Sep;128(1):158-64. PMID 10498847
  6. ^ Saxena PR, Lawang A. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Archives Internationales de Pharmacodynamie et de Therapie. 1985 Oct;277(2):235-52. PMID 2933009
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