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5-Fluoro-DMT: Wikis


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5-Fluoro-DMT
Systematic (IUPAC) name
2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
Identifiers
CAS number 22120-36-1
ATC code  ?
PubChem 2762738
Chemical data
Formula C 12H15FN2  
Mol. mass 206.259 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

5-Fluoro-N,N-dimethyltryptamine (5-F-DMT) is a tryptamine derivative related to compounds such as 5-Bromo-DMT and 5-Methoxy-DMT. Fluorination of hallucinogenic tryptamines either reduces or has little effect on 5-HT2A/C receptor affinity or efficacy, although 6-fluoro-DET is inactive as a hallucinogen despite acting as a 5-HT2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT1A than 5-HT2A.[1][2]

See also

References

  1. ^ Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 2000 Nov 30;43(24):4701-10. PMID 11101361
  2. ^ Rabin RA, Regina M, Doat M, Winter JC. 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacology, Biochemistry and Behaviour. 2002 May;72(1-2):29-37. PMID 11900766







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