5-HT1B receptor: Wikis

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5-hydroxytryptamine (serotonin) receptor 1B
Identifiers
Symbols HTR1B; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
External IDs OMIM182131 MGI96274 HomoloGene669 IUPHAR: 5-HT1B GeneCards: HTR1B Gene
RNA expression pattern
PBB GE HTR1B 210799 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3351 15551
Ensembl ENSG00000135312 ENSMUSG00000049511
UniProt P28222 Q0VES5
RefSeq (mRNA) NM_000863 NM_010482
RefSeq (protein) NP_000854 NP_034612
Location (UCSC) Chr 6:
78.23 - 78.23 Mb
Chr 9:
81.43 - 81.43 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1B, also known as HTR1B, is a human 5-HT receptor, but also denotes the gene encoding it.[1]

Contents

Tissue distribution and function

5-HT1B acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.

5-HT1B receptors are present in many parts of the human brain. The highest concentrations are found in the basal ganglia, striatum and the frontal cortex. The function of the receptor differs between the areas: in the frontal cortex it is believed to act as a terminal receptor, inhibiting the release of dopamine. In the striatum and the basal ganglia, the 5-HT1B receptor is thought to act as an autoreceptor, inhibiting the release of serotonin.

Knockout mice lacking the 5-HT1B gene has shown an increase of aggression and a higher preference for alcohol.[2]

Ligands

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Agonists

Antagonists and inverse agonists

Genetics

In humans the protein is coded by the gene HTR1B.

A genetic variant in the promotor region, A-161T, has been examined with respect to personality traits and showed no major effect.[6]

See also

References

  1. ^ "Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351.  
  2. ^ Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacol. Biochem. Behav. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546.  
  3. ^ Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C. Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1072-84. PMID 12604684
  4. ^ Selkirk JV, Scott C, Ho M, Burton MJ, Watson J, Gaster LM, Collin L, Jones BJ, Middlemiss DN, Price GW. SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. British Journal of Pharmacology. 1998 Sep;125(1):202-8. PMID 9776361
  5. ^ Roberts C, Watson J, Price GW, Middlemiss DN. SB-236057-A: a selective 5-HT1B receptor inverse agonist. CNS Drug Reviews. 2001 Winter;7(4):433-44. PMID 11830759
  6. ^ Tsai SJ, Wang YC, Chen JY, Hong CJ (2003). "Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits". Neuropsychobiology 48 (2): 68–71. doi:10.1159/000072879. PMID 14504413.  

External links

Further reading

  • Olivier B, van Oorschot R (2006). "5-HT1B receptors and aggression: a review.". Eur. J. Pharmacol. 526 (1-3): 207–17. doi:10.1016/j.ejphar.2005.09.066. PMID 16310769.  
  • Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.". Biochem. Biophys. Res. Commun. 184 (2): 752–9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531.  
  • Veldman SA, Bienkowski MJ (1992). "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype.". Mol. Pharmacol. 42 (3): 439–44. PMID 1328844.  
  • Jin H, Oksenberg D, Ashkenazi A, et al. (1992). "Characterization of the human 5-hydroxytryptamine1B receptor.". J. Biol. Chem. 267 (9): 5735–8. PMID 1348246.  
  • Demchyshyn L, Sunahara RK, Miller K, et al. (1992). "A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5522–6. doi:10.1073/pnas.89.12.5522. PMID 1351684.  
  • Levy FO, Gudermann T, Perez-Reyes E, et al. (1992). "Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype.". J. Biol. Chem. 267 (11): 7553–62. PMID 1559993.  
  • Weinshank RL, Zgombick JM, Macchi MJ, et al. (1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. doi:10.1073/pnas.89.8.3630. PMID 1565658.  
  • Mochizuki D, Yuyama Y, Tsujita R, et al. (1992). "Cloning and expression of the human 5-HT1B-type receptor gene.". Biochem. Biophys. Res. Commun. 185 (2): 517–23. doi:10.1016/0006-291X(92)91655-A. PMID 1610347.  
  • Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P (1995). "Identification of genetic variation in the human serotonin 1D beta receptor gene.". Biochem. Biophys. Res. Commun. 205 (2): 1194–200. doi:10.1006/bbrc.1994.2792. PMID 7802650.  
  • Ng GY, George SR, Zastawny RL, et al. (1993). "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.". Biochemistry 32 (43): 11727–33. doi:10.1021/bi00094a032. PMID 8218242.  
  • Bouchelet I, Cohen Z, Case B, et al. (1996). "Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels.". Mol. Pharmacol. 50 (2): 219–23. PMID 8700126.  
  • Sanders AR, Cao Q, Taylor J, et al. (2001). "Genetic diversity of the human serotonin receptor 1B (HTR1B) gene.". Genomics 72 (1): 1–14. doi:10.1006/geno.2000.6411. PMID 11247661.  
  • Varnäs K, Hall H, Bonaventure P, Sedvall G (2001). "Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743.". Brain Res. 915 (1): 47–57. doi:10.1016/S0006-8993(01)02823-2. PMID 11578619.  
  • Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc. M201539200. PMID 11854302.  
  • Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H (2002). "Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2.". Journal of neural transmission (Vienna, Austria : 1996) 109 (4): 513–21. doi:10.1007/s007020200042. PMID 11956970.  
  • Hawi Z, Dring M, Kirley A, et al. (2003). "Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample.". Mol. Psychiatry 7 (7): 718–25. doi:10.1038/sj.mp.4001048. PMID 12192616.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Huang YY, Oquendo MA, Friedman JM, et al. (2003). "Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.". Neuropsychopharmacology 28 (1): 163–9. doi:10.1038/sj.npp.1300000. PMID 12496953.  
  • Quist JF, Barr CL, Schachar R, et al. (2003). "The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder.". Mol. Psychiatry 8 (1): 98–102. doi:10.1038/sj.mp.4001244. PMID 12556913.  
  • Sinha R, Cloninger CR, Parsian A (2003). "Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 121 (1): 83–8. doi:10.1002/ajmg.b.20064. PMID 12898580.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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