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5-HT1F receptor: Wikis

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5-hydroxytryptamine (serotonin) receptor 1F
Identifiers
Symbols HTR1F; 5-HT1F; HTR1EL; MR77
External IDs OMIM182134 MGI99842 HomoloGene37361 IUPHAR: 5-HT1F GeneCards: HTR1F Gene
RNA expression pattern
PBB GE HTR1F 221458 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3355 15557
Ensembl ENSG00000179097 ENSMUSG00000050783
UniProt P30939 Q543V2
RefSeq (mRNA) NM_000866 NM_008310
RefSeq (protein) NP_000857 NP_032336
Location (UCSC) Chr 3:
88.12 - 88.12 Mb
Chr 16:
64.87 - 65.05 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.[1][2][3][4][5]

Contents

Ligands

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Agonists

Antagonists

No selective 5HT1F antagonists are available as yet.

See also

References

  1. ^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355.  
  2. ^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (January 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMID 8380639. PMC 45671. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8380639.  
  3. ^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (March 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMID 8384716. PMC 46050. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8384716.  
  4. ^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Mol. Membr. Biol. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.  
  5. ^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (June 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.  
  6. ^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). "[3H]-LY-334,370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510.  
  7. ^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorg. Med. Chem. Lett. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.  

External links

Further reading

  • Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors.". Pharmacol. Biochem. Behav. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546.  
  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.  
  • Amlaiky N, Ramboz S, Boschert U, et al. (1992). "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus.". J. Biol. Chem. 267 (28): 19761–4. PMID 1328180.  
  • Adham N, Kao HT, Schecter LE, et al. (1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMID 8380639.  
  • Lovenberg TW, Erlander MG, Baron BM, et al. (1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMID 8384716.  
  • Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, et al. (1999). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients.". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bhatnagar A, Sheffler DJ, Kroeze WK, et al. (2004). "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.". J. Biol. Chem. 279 (33): 34614–23. doi:10.1074/jbc.M404673200. PMID 15190056.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, et al. (2006). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.". PLoS Genet. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMID 16254601.  


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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