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5-Iodo-2-aminoindane
Systematic (IUPAC) name
5-iodo-2,3-dihydro-1H-inden-2-amine
Identifiers
CAS number 132367-76-1
ATC code  ?
PubChem 131506
Chemical data
Formula C 9H10IN 
Mol. mass 259.087 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status legal
Routes  ?

5-Iodo-2-aminoindan (5-IAI) is a psychoactive drug and research chemical developed in the 1990s by a team led by David E. Nichols at Purdue University.[1] It acts as a selective serotonin releasing agent (SSRA). Unlike similar compounds like MDAI, 5-IAI does cause some neurotoxicity, but is substantially less toxic than the corresponding amphetamine p-iodoamphetamine (PIA).[2] 5-IAI was developed to aid in the investigation of the serotonergic neurotoxicity caused by the para-halogenated amphetamines such as p-chloroamphetamine (PCA).

References

  1. ^ Nichols DE, Johnson MP, Oberlender R. (1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine.". Pharmacol Biochem Behav. 38 (1): 135–139. PMID 1826785.  
  2. ^ Johnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology 200 (1): 9–16. PMID 1685125.  
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