The Full Wiki

More info on 5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine

5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine
Systematic (IUPAC) name
(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-methoxyindole
Identifiers
CAS number  ?
ATC code  ?
PubChem 9881324
Chemical data
Formula C 15H19N2O 
Mol. mass 243.323 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine (also known as (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-methoxyindole) is a tryptamine derivative that is a hallucinogenic drug. It was first developed by the team led by JE Macor in 1992,[1] and subsequently investigated by the team led by David Nichols from Purdue University in the late 1990s. This compound produces hallucinogen-appropriate responding in animal tests with a similar potency to the amphetamine derived hallucinogen DOI, and has two enantiomers, with only the (R) enantiomer being active.[2]

See also

References

  1. ^ Macor JE, Blake J, Fox CB, Johnson C, Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al. Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. Journal of Medicinal Chemistry. 1992 Nov 13;35(23):4503-5. PMID 1447752
  2. ^ Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE. Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. Journal of Medicinal Chemistry. 1999 Oct 7;42(20):4257-63. PMID 10514296
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message