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5-Methoxytryptamine: Wikis


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Systematic (IUPAC) name
CAS number 608-07-1
ATC code  ?
PubChem 1833
ChemSpider 1767
Chemical data
Formula C 11H14N2O 
Mol. mass 190.242 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine drug and research chemical closely related to the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT) and melatonin (N-acetyl-5-methoxytryptamine). 5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.[1][2][3][4][5][6] [7] It has no affinity for the 5-HT3 receptor and it should also be noted that its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors.[4][8 ] Its affinity for the 5-HT5A receptor is unknown. 5-MT has been shown to occur naturally in the body in low levels.[9] It is synthesized from melatonin in the pineal gland.[9]

See also


  1. ^ Wu PH, Gurevich N, Carlen PL. (1988). "Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.". Neurosci Lett. 86 (1): 72–76. PMID 2966313.  
  2. ^ Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K. (1997). "Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.". Eur J Pharmacol. 323 (2-3): 235–240. PMID 9128844.  
  3. ^ Amemiya N, Hatta S, Takemura H, Ohshika H. (1996). "Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.". Eur J Pharmacol. 318 (2-3): 403–409. PMID 9016931.  
  4. ^ a b Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE. (1990). "5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.". Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9–16. PMID 2402303.  
  5. ^ Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ. (1997). "Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.". Neuropharmacology. 36 (4-5): 713–720. PMID 9225298.  
  6. ^ Hemedah M, Coupar IM, Mitchelson FJ. (1999). "[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.". Br J Pharmacol. 126 (1): 179–188. PMID 10051134.  
  7. ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Retrieved 2008-04-11.  
  8. ^ Roth, Brian (2006). The serotonin receptors. Humana Press. p. 133. ISBN 1588295680, 9781588295682.  
  9. ^ a b Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ. (1988). "Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).". J Endocrinol. 118 (3): 389–397. PMID 2460575.  

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