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5S ribosomal RNA: Wikis


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5S ribosomal RNA
Type: Gene;rRNA;
2° structure: Published; PubMed
Seed alignment: Szymanski et al., 5S ribosomal database, PubMed
Avg length: 115.80 nucleotides
Avg identity: 43.00%
A 3D representation of a 5S rRNA molecule. This structure is of the 5S rRNA from the Escherichia coli 50S ribosomal subunit and is based on a cryo-electron microscopic reconstruction.[1]
A 3D representation of the ribosome.[2]

5S ribosomal RNA (5S rRNA) is a component of the large ribosomal subunit in both prokaryotes and eukaryotes.

  • In prokaryotes, it is part of the 50S subunit.
  • In eukaryotes, it is synthesised by RNA polymerase III (the other eukaryotic rRNAs are cleaved from a 45S precursor synthesized by RNA polymerase I). In Xenopus oocytes, it has been shown that fingers 4-7 of the nine-zinc finger transcription factor TFIIIA can bind to the central region of 5S RNA.[3] Binding between 5S rRNA and TFIIIA serves to both repress further transcription of the 5S RNA gene and stabilize the 5S RNA transcript until it is required for ribosome assembly.[4]


  1. ^ Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R (2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution.". J Mol Biol 298 (1): 35-59. PMID 10756104.  
  2. ^ Mitra K, Schaffitzel C, Fabiola F, Chapman MS, Ban N, Frank J (2006). "Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements.". Mol Cell 22 (4): 533-43. PMID 16713583.  
  3. ^ Searles, MA; Lu D, Klug A (2000). "The role of the central zinc fingers of transcription factor IIIA in binding to 5 S RNA". J Mol Biol 301: 47–60. doi:10.1006/jmbi.2000.3946. PMID 10926492.  
  4. ^ Pelham, HRB; Brown DD (1980). "A specific transcription factor that can bind either the 5S RNA gene or 5S RNA". Proc Natl Acad Sci 77: 4170–4174. doi:10.1073/pnas.77.7.4170. PMID 7001457.  

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