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6-Fluoronorepinephrine: Wikis

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6-Fluoronorepinephrine
Systematic (IUPAC) name
4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
Identifiers
CAS number 86820-21-5
ATC code none
PubChem 1862
ChemSpider 1792
Chemical data
Formula C8H10FNO3 
Mol. mass 187.17 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled

6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]

See also

  • 2-Fluoronorepinephrine
  • 5-Fluoronorepinephrine

References

  1. ^ a b Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry 22 (12): 1493–7. PMID 231654. 
  2. ^ a b c Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist". Brain Research 1291: 21–31. doi:10.1016/j.brainres.2009.07.049. PMID 19632210. http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01470-X. 
  3. ^ Stone EA, Grunewald GL, Lin Y, et al. (July 2003). "Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice". Synapse (New York, N.Y.) 49 (1): 67–76. doi:10.1002/syn.10212. PMID 12710017. http://dx.doi.org/10.1002/syn.10212. 
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