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7-OH-DPAT: Wikis

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7-OH-DPAT
Systematic (IUPAC) name
7-Hydroxy-N,N-dipropyl-2-aminotetralin
Identifiers
CAS number 159795-63-8
ATC code  ?
PubChem 1219
Chemical data
Formula C 16H25NO 
Mol. mass 247.38 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype,[1][2][3] and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT.[4][5][6]

See also

References

  1. ^ Mulder TB, de Vries JB, Dijkstra D, Wiechers JW, Grol CJ, Horn AS (November 1987). "Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology 336 (5): 494–501. PMID 2830544.  
  2. ^ Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (September 1992). "Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3Hhydroxy-N,N-di-n-propyl-2-aminotetralin"]. Proceedings of the National Academy of Sciences of the United States of America 89 (17): 8155–9. PMID 1518841.  
  3. ^ Lévesque D (August 1996). "Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?". Biochemical Pharmacology 52 (4): 511–8. PMID 8759022.  
  4. ^ Arvidsson LE, Johansson AM, Hacksell U, Nilsson JL, Svensson K, Hjorth S, Magnusson T, Carlsson A, Andersson B, Wikström H (November 1987). "(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal Chemistry 30 (11): 2105–9. PMID 2959776.  
  5. ^ Malmberg A, Nordvall G, Johansson AM, Mohell N, Hacksell U (August 1994). "Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors". Molecular Pharmacology 46 (2): 299–312. PMID 8078492.  
  6. ^ Eltayb A, Lindblom S, Oerther S, Ahlenius S (July 2001). "Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat". Acta Physiologica Scandinavica 172 (3): 205–9. PMID 11472307.  
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