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8-Hydroxy-N,N-dipropyl-2-aminotetralin
Systematic (IUPAC) name
8-Hydroxy-N,N-dipropyl-2-aminotetralin
Identifiers
CAS number 78950-78-4
ATC code  ?
PubChem 1220
Chemical data
Formula C 16H25NO 
Mol. mass 247.38 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1.56 hour
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

8-Hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) is a psychoactive drug and research chemical used widely in scientific research. It acts as a 5-HT1A and 5-HT7 receptor full agonist,[1][2] [3] and to a lesser extent, as a serotonin reuptake inhibitor[4] and releasing agent.[5] In animal studies, 8-OH-DPAT has antidepressant,[6] anxiolytic,[7] serenic,[8] anorectic,[9] antiemetic,[10] hypothermic,[11] hypotensive,[12] bradycardic,[12] hyperventilative,[13] and analgesic effects.[14]

See also

References

  1. ^ Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (February 1990). "Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT". Neuropharmacology 29 (2): 85–91. PMID 1691832.  
  2. ^ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (January 2004). "8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production". Neuropharmacology 46 (1): 52–62. PMID 14654097. http://linkinghub.elsevier.com/retrieve/pii/S0028390803003472.  
  3. ^ "IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7". http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2337.  
  4. ^ Assié MB, Koek W (November 1996). "Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats". British Journal of Pharmacology 119 (5): 845–50. PMID 8922730.  
  5. ^ Wölfel R, Graefe KH (February 1992). "Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter". Naunyn-Schmiedeberg's Archives of Pharmacology 345 (2): 129–36. PMID 1570019.  
  6. ^ Luscombe GP, Martin KF, Hutchins LJ, Gosden J, Heal DJ (March 1993). "Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors". British Journal of Pharmacology 108 (3): 669–77. PMID 8467355.  
  7. ^ Schreiber R, De Vry J (November 1993). "Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat". European Journal of Pharmacology 249 (3): 341–51. PMID 7904566.  
  8. ^ de Boer SF, Koolhaas JM (December 2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". European Journal of Pharmacology 526 (1-3): 125–39. doi:10.1016/j.ejphar.2005.09.065. PMID 16310183.  
  9. ^ Dourish CT, Hutson PH, Curzon G (October 1985). "Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin 15 (4): 377–84. PMID 2933126. http://linkinghub.elsevier.com/retrieve/pii/0361-9230(85)90005-X.  
  10. ^ Lucot JB (February 1994). "Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin". European Journal of Pharmacology 253 (1-2): 53–60. PMID 8013549.  
  11. ^ O'Connell MT, Sarna GS, Curzon G (July 1992). "Evidence for postsynaptic mediation of the hypothermic effect of 5-HT1A receptor activation". British Journal of Pharmacology 106 (3): 603–9. PMID 1387027.  
  12. ^ a b Fozard JR, Mir AK, Middlemiss DN (March 1987). "Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular Pharmacology 9 (3): 328–47. PMID 2437400.  
  13. ^ Meyer LC, Fuller A, Mitchell D (February 2006). "Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290 (2): R405–13. doi:10.1152/ajpregu.00440.2005. PMID 16166206.  
  14. ^ Xu W, Qiu XC, Han JS (June 1994). "Serotonin receptor subtypes in spinal antinociception in the rat". The Journal of Pharmacology and Experimental Therapeutics 269 (3): 1182–9. PMID 8014862. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=8014862.  
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