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More info on 8a-Phenyldecahydroquinoline

8a-Phenyldecahydroquinoline: Wikis


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Systematic (IUPAC) name
CAS number 131556-11-1
ATC code  ?
PubChem 131397
ChemSpider 116144
Chemical data
Formula C 15H21N 
Mol. mass 215.3339 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist. It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.[1][2]


  1. ^ Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP (1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". J Med Chem 35 (9): 1634–8. doi:10.1021/jm00087a020.  
  2. ^ Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC (2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". J Mol Model 8 (2): 65–72. doi:10.1007/s00894-001-0067-4.  


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