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9-Aminomethyl-9,10-dihydroanthracene
Systematic (IUPAC) name
9-Aminomethyl-9,10-dihydroanthracene
Identifiers
CAS number  ?
ATC code  ?
PubChem 10398175
Chemical data
Formula C 15H15N 
Mol. mass 209.286 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

AMDA (9-Aminomethyl-9,10-dihydroanthracene) is an organic compound which acts as a potent and selective antagonist for the 5-HT2A receptor.[1] It has been used to help study the shape of the 5-HT2A protein,[2] and develop a large family of related derivatives with even higher potency and selectivity.[3][4][5][6]

References

  1. ^ Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist. European Journal of Pharmacology. 1999 Sep 3;380(1):R5-7. PMID 10513561
  2. ^ Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Journal of Medicinal Chemistry. 2002 Apr 11;45(8):1656-64. PMID 11931619
  3. ^ Peddi S, Roth BL, Glennon RA, Westkaemper RB. Spiro[9,10-dihydroanthracene]-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist. European Journal of Pharmacology. 2003 Dec 15;482(1-3):335-7. PMID 14660041
  4. ^ Peddi S, Roth BL, Glennon RA, Westkaemper RB. Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). Bioorganic and Medicinal Chemistry Letters. 2004 May 3;14(9):2279-83. PMID 15081025
  5. ^ Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorganic and Medicinal Chemistry Letters. 2008 Oct 1;18(19):5268-71. PMID 18774714
  6. ^ Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. Journal of Medicinal Chemistry. 2008 Nov 13;51(21):6808-28. PMID 18847250
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