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A-366,833
Systematic (IUPAC) name
5-[(1S,5R)-3,6-diazabicyclo[3.2.0]hept-6-yl]pyridine-3-carbonitrile
Identifiers
CAS number  ?
ATC code  ?
PubChem 9834234
Chemical data
Formula C 11H12N4  
Mol. mass 200.239
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

A-366,833 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype, and has been researched for use as an analgesic, although it has not passed clinical trials.[1][2]

References

  1. ^ Ji, J.; Bunnelle, W.; Anderson, D.; Faltynek, C.; Dyhring, T.; Ahring, P.; Rueter, L.; Curzon, P. et al. (2007). "A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo3.2.0-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical pharmacology 74 (8): 1253–1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775.   edit
  2. ^ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem 2 (6): 746–767. doi:10.1002/cmdc.200600207. PMID 17295372.   edit
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