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A-372,159: Wikis

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A-372,159
Systematic (IUPAC) name
(11S,16R)-3-[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]-6-oxa-10,14-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1,3,5(17)-triene
Identifiers
ATC code  ?
Chemical data
Formula C24H27F3N2O2 
Mol. mass 432.478 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

A-372,159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]

References

  1. ^ Childers WE, Robichaud AJ. Recent Advances in Selective Serotonergic Agents. Annual Reports in Medicinal Chemistry 2005; Volume 40:17-33. ISBN 978-0-12-040540-4
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