The Full Wiki

More info on AB5 toxin

AB5 toxin: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Cholera toxin, an AB5 toxin. the A subunit is red and orange; the B subunit is blue. A portion of the B subunit complex has been rendered partially transparent to show the bound tail of the A2 chain.

The AB5 (or AB5) toxins are six-component protein complexes secreted by a number of pathogenic bacteria. All share a similar structure and mechanism for entering targeted host cells.[1]

Structure and mechanism

A complete AB5 toxin complex contains six protein units. Five – the B subunits – are similar or identical in structure; the remaining A subunit is unique.

The A subunit (or a portion thereof) of an AB5 toxin is the portion of the complex responsible for toxicity. Typically it will have enzymatic activity inside the host cell.

The B subunits form a pentameric (five-membered) ring, into which one end of the A subunit extends and is held. This B subunit ring is also capable of binding to a receptor on the surface of the host cell.[2] (Without the B subunits, the A subunit has no way of attaching to or entering the cell, and thus no way to exert its toxic effect.)

List of AB5 toxins

References

  1. ^ Merritt E, Hol W (1995). "AB5 toxins". Curr Opin Struct Biol 5 (2): 165–71. doi:10.1016/0959-440X(95)80071-9. PMID 7648317.  
  2. ^ Lencer W, Saslowsky D (2005). "Raft trafficking of AB5 subunit bacterial toxins". Biochim Biophys Acta 1746 (3): 314–21. doi:10.1016/j.bbamcr.2005.07.007. PMID 16153723.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message