The Full Wiki

More info on ABCA7

ABCA7: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

ATP-binding cassette, sub-family A (ABC1), member 7
Symbols ABCA7; ABCA-SSN; ABCX; FLJ40025
External IDs OMIM605414 MGI1351646 HomoloGene22783 GeneCards: ABCA7 Gene
RNA expression pattern
PBB GE ABCA7 219577 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10347 27403
Ensembl ENSG00000064687 ENSMUSG00000035722
UniProt Q8IZY2 Q8R1I3
RefSeq (mRNA) NM_019112 NM_013850
RefSeq (protein) NP_061985 NP_038878
Location (UCSC) Chr 19:
0.99 - 1.02 Mb
Chr 10:
79.4 - 79.42 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family A member 7 is a protein that in humans is encoded by the ABCA7 gene.[1]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. Alternative splicing of this gene results in two transcript variants.[1]


See also


Further reading

  • Kaminski WE, Orsó E, Diederich W, et al. (2000). "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).". Biochem. Biophys. Res. Commun. 273 (2): 532–8. doi:10.1006/bbrc.2000.2954. PMID 10873640.  
  • Niwa M, Maruyama H, Fujimoto T, et al. (2001). "Affinity selection of cDNA libraries by lambda phage surface display.". Gene 256 (1-2): 229–36. doi:10.1016/S0378-1119(00)00348-6. PMID 11054552.  
  • Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.". Biochem. Biophys. Res. Commun. 278 (3): 782–9. doi:10.1006/bbrc.2000.3880. PMID 11095984.  
  • Tanaka AR, Ikeda Y, Abe-Dohmae S, et al. (2001). "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome.". Biochem. Biophys. Res. Commun. 283 (5): 1019–25. doi:10.1006/bbrc.2001.4891. PMID 11355874.  
  • Broccardo C, Osorio J, Luciani MF, et al. (2001). "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.". Cytogenet. Cell Genet. 92 (3-4): 264–70. doi:10.1159/000056914. PMID 11435699.  
  • Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.". J. Hum. Genet. 47 (6): 285–310. doi:10.1007/s100380200041. PMID 12111378.  
  • Wang N, Lan D, Gerbod-Giannone M, et al. (2003). "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.". J. Biol. Chem. 278 (44): 42906–12. doi:10.1074/jbc.M307831200. PMID 12917409.  
  • Kielar D, Kaminski WE, Liebisch G, et al. (2003). "Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization.". J. Invest. Dermatol. 121 (3): 465–74. doi:10.1046/j.1523-1747.2003.12404.x. PMID 12925201.  
  • Abe-Dohmae S, Ikeda Y, Matsuo M, et al. (2004). "Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.". J. Biol. Chem. 279 (1): 604–11. doi:10.1074/jbc.M309888200. PMID 14570867.  
  • Ikeda Y, Abe-Dohmae S, Munehira Y, et al. (2004). "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.". Biochem. Biophys. Res. Commun. 311 (2): 313–8. doi:10.1016/j.bbrc.2003.10.002. PMID 14592415.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.  
  • Hayashi M, Abe-Dohmae S, Okazaki M, et al. (2005). "Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.". J. Lipid Res. 46 (8): 1703–11. doi:10.1194/jlr.M500092-JLR200. PMID 15930518.  
  • Jehle AW, Gardai SJ, Li S, et al. (2006). "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.". J. Cell Biol. 174 (4): 547–56. doi:10.1083/jcb.200601030. PMID 16908670.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address