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ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Symbols ABCC10; MRP7; EST182763; SIMRP7
External IDs MGI2386976 HomoloGene58616 GeneCards: ABCC10 Gene
RNA expression pattern
PBB GE ABCC10 213485 s at tn.png
PBB GE ABCC10 215873 x at tn.png
More reference expression data
Species Human Mouse
Entrez 89845 224814
Ensembl ENSG00000124574 ENSMUSG00000032842
UniProt Q5T3U5 Q8R4P9
RefSeq (mRNA) NM_033450 NM_145140
RefSeq (protein) NP_258261 NP_660122
Location (UCSC) Chr 6:
43.5 - 43.53 Mb
Chr 17:
45.77 - 45.79 Mb
PubMed search [1] [2]

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.[1][2]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[2]


See also


  1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum Mol Genet 5 (10): 1649-55. PMID 8894702.  
  2. ^ a b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".  

Further reading

  • Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily.". Cancer Lett. 162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID 11146224.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).". Mol. Pharmacol. 63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID 12527806.  
  • Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7.". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel.". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465.  
  • Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis.". J. Immunol. 175 (3): 1383–7. PMID 16034073.  
  • Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.". Int. J. Oncol. 30 (2): 393–401. PMID 17203221.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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