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ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Symbols ABCC11; MRP8; EWWD; WW
External IDs OMIM607040 HomoloGene69511 GeneCards: ABCC11 Gene
Species Human Mouse
Entrez 85320 n/a
Ensembl ENSG00000121270 n/a
UniProt Q96J66 n/a
RefSeq (mRNA) NM_032583 n/a
RefSeq (protein) NP_115972 n/a
Location (UCSC) Chr 16:
46.76 - 46.84 Mb
PubMed search [1] n/a

ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11 gene.[1][2][3]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, an SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.[3]


See also


  1. ^ Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M, Allikmets R (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene 273 (1): 89-96. PMID 11483364.  
  2. ^ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res 11 (7): 1156-66. PMID 11435397.  
  3. ^ a b "Entrez Gene: ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11".  

Further reading

  • Bera TK, Lee S, Salvatore G, et al. (2002). "MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.". Mol. Med. 7 (8): 509–16. PMID 11591886.  
  • Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.". Biochem. Biophys. Res. Commun. 288 (4): 933–9. doi:10.1006/bbrc.2001.5865. PMID 11688999.  
  • Lai L, Tan TM (2002). "Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues.". Biochem. J. 361 (Pt 3): 497–503. doi:10.1042/0264-6021:3610497. PMID 11802779.  
  • Stríz I, Jaresová M, Lácha J, et al. (2002). "MRP 8/14 and procalcitonin serum levels in organ transplantations.". Ann. Transplant. 6 (2): 6–9. PMID 11803621.  
  • Tomita H, Yamada K, Ghadami M, et al. (2002). "Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16.". Lancet 359 (9322): 2000–2. doi:10.1016/S0140-6736(02)08835-9. PMID 12076558.  
  • Turriziani O, Schuetz JD, Focher F, et al. (2002). "Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.". Biochem. J. 368 (Pt 1): 325–32. doi:10.1042/BJ20020494. PMID 12133003.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Guo Y, Kotova E, Chen ZS, et al. (2003). "MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.". J. Biol. Chem. 278 (32): 29509–14. doi:10.1074/jbc.+M304059200. PMID 12764137.  
  • Bouma G, Lam-Tse WK, Wierenga-Wolf AF, et al. (2004). "Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin.". Diabetes 53 (8): 1979–86. doi:10.2337/diabetes.53.8.1979. PMID 15277376.  
  • Vogl T, Ludwig S, Goebeler M, et al. (2005). "MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes.". Blood 104 (13): 4260–8. doi:10.1182/blood-2004-02-0446. PMID 15331440.  
  • Chen ZS, Guo Y, Belinsky MG, et al. (2005). "Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).". Mol. Pharmacol. 67 (2): 545–57. doi:10.1124/mol.104.007138. PMID 15537867.  
  • Bortfeld M, Rius M, König J, et al. (2006). "Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.". Neuroscience 137 (4): 1247–57. doi:10.1016/j.neuroscience.2005.10.025. PMID 16359813.  
  • Yoshiura K, Kinoshita A, Ishida T, et al. (2006). "A SNP in the ABCC11 gene is the determinant of human earwax type.". Nat. Genet. 38 (3): 324–30. doi:10.1038/ng1733. PMID 16444273.  
  • Viemann D, Barczyk K, Vogl T, et al. (2007). "MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program.". Blood 109 (6): 2453–60. doi:10.1182/blood-2006-08-040444. PMID 17095618.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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