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ATP-binding cassette, sub-family G (WHITE), member 2
Identifiers
Symbols ABCG2; MRX; BCRP1; ABC15; ABCP; BCRP; BMDP; CDw338; EST157481; MGC102821; MXR; MXR1
External IDs OMIM603756 MGI1347061 HomoloGene55852 GeneCards: ABCG2 Gene
RNA expression pattern
PBB GE ABCG2 209735 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9429 26357
Ensembl ENSG00000118777 ENSMUSG00000029802
UniProt Q9UNQ0 Q7TMS5
RefSeq (mRNA) NM_004827 NM_011920
RefSeq (protein) NP_004818 NP_036050
Location (UCSC) Chr 4:
89.23 - 89.3 Mb
Chr 6:
58.53 - 58.62 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.[1][2] ABCG2 has also been designated as CDw338 (cluster of differentiation w338).

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.[3]

Contents

See also

References

  1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet 5 (10): 1649-55. PMID 8894702.  
  2. ^ Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD (Jan 1999). "A multidrug resistance transporter from human MCF-7 breast cancer cells". Proc Natl Acad Sci U S A 95 (26): 15665-70. PMID 9861027.  
  3. ^ "Entrez Gene: ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9429.  

Further reading

  • Hazai E, Bikadi Z. (2008). "Homology modeling of breast cancer resistance protein (ABCG2).". J Struct Biol. 162 (1): 63–74. doi:10.1016/j.jsb.2007.12.001. PMID 18249138.  
  • Abbott BL (2006). "ABCG2 (BCRP): a cytoprotectant in normal and malignant stem cells". Clin Adv Hematol Oncol. 4 (1): 63–72. PMID 16562373.  
  • Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism.". J. Lipid Res. 42 (10): 1513–20. PMID 11590207.  
  • Ejendal KF, Hrycyna CA (2003). "Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.". Curr. Protein Pept. Sci. 3 (5): 503–11. doi:10.2174/1389203023380521. PMID 12369998.  
  • Doyle LA, Ross DD (2003). "Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).". Oncogene 22 (47): 7340–58. doi:10.1038/sj.onc.1206938. PMID 14576842.  
  • Sugimoto Y, Tsukahara S, Ishikawa E, Mitsuhashi J (2005). "Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.". Cancer Sci. 96 (8): 457–65. doi:10.1111/j.1349-7006.2005.00081.x. PMID 16108826.  
  • Ishikawa T, Tamura A, Saito H, et al. (2006). "Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.". Naturwissenschaften 92 (10): 451–63. doi:10.1007/s00114-005-0019-4. PMID 16160819.  
  • Krishnamurthy P, Schuetz JD (2006). "Role of ABCG2/BCRP in biology and medicine.". Annu. Rev. Pharmacol. Toxicol. 46: 381–410. doi:10.1146/annurev.pharmtox.46.120604.141238. PMID 16402910.  
  • Robey RW, Polgar O, Deeken J, et al. (2007). "ABCG2: determining its relevance in clinical drug resistance.". Cancer Metastasis Rev. 26 (1): 39–57. doi:10.1007/s10555-007-9042-6. PMID 17323127.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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