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ADAM metallopeptidase domain 8
Symbols ADAM8; CD156; MGC134985; MS2
External IDs OMIM602267 MGI107825 HomoloGene74384 GeneCards: ADAM8 Gene
RNA expression pattern
PBB GE ADAM8 205180 s at tn.png
PBB GE ADAM8 205179 s at tn.png
More reference expression data
Species Human Mouse
Entrez 101 11501
Ensembl ENSG00000151651 ENSMUSG00000025473
UniProt P78325 Q3TVN5
RefSeq (mRNA) NM_001109 NM_007403
RefSeq (protein) NP_001100 NP_031429
Location (UCSC) Chr 10:
134.93 - 134.94 Mb
Chr 7:
139.83 - 139.84 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[2]

See also


  1. ^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (May 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56-62. doi:10.1006/geno.1997.4607. PMID 9126482.  
  2. ^ a b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".  

Further reading

  • Yamamoto S, Higuchi Y, Yoshiyama K, et al. (1999). "ADAM family proteins in the immune system.". Immunol. Today 20 (6): 278–84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.  
  • Schlomann U, Rathke-Hartlieb S, Yamamoto S, et al. (2001). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration.". J. Neurosci. 20 (21): 7964–71. PMID 11050116.  
  • Amour A, Knight CG, English WR, et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.". FEBS Lett. 524 (1-3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ishikawa N, Daigo Y, Yasui W, et al. (2005). "ADAM8 as a novel serological and histochemical marker for lung cancer.". Clin. Cancer Res. 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Foley SC, Mogas AK, Olivenstein R, et al. (2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma.". J. Allergy Clin. Immunol. 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.  
  • Gómez-Gaviro M, Domínguez-Luis M, Canchado J, et al. (2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.". J. Immunol. 178 (12): 8053–63. PMID 17548643.  
  • Valkovskaya N, Kayed H, Felix K, et al. (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.". J. Cell. Mol. Med. 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID 17979891.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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