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AL-37350A
Systematic (IUPAC) name
(S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
Identifiers
CAS number  ?
ATC code  ?
PubChem 10331436
Chemical data
Formula C 14H18N2O 
Mol. mass 230.305 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

AL-37350A is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treament of glaucoma.[1]

See also

References

  1. ^ May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95. doi:10.1021/jm030205t. PMID 12954071.  
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