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From Wikipedia, the free encyclopedia

alkaline phosphatase, intestinal
Symbols ALPI; IAP
External IDs OMIM171740 MGI1924018 HomoloGene79555 GeneCards: ALPI Gene
EC number
Species Human Mouse
Entrez 248 76768
Ensembl ENSG00000163295 ENSMUSG00000079440
UniProt P09923 Q0VD75
RefSeq (mRNA) NM_001631 NM_001081082
RefSeq (protein) NP_001622 NP_001074551
Location (UCSC) Chr 2:
233.03 - 233.03 Mb
Chr 1:
88.99 - 89 Mb
PubMed search [1] [2]

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.[1][2]


  1. ^ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. PMID 3468508. 
  2. ^ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. PMID 3469665. 

Further reading

  • Hirasaka K, Tokuoka K, Nakao R, et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells.". J Physiol Sci 58 (2): 105-11. doi:10.2170/physiolsci.RP013007. PMID 18307834. 
  • Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433-41. doi:10.1152/ajpgi.00466.2002. PMID 12660142. 
  • Wada A, Wang AP, Isomoto H, et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.". Int. J. Med. Microbiol. 294 (7): 427-35. PMID 15715171. 
  • Nakano T, Inoue I, Alpers DH, et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207-14. doi:10.1152/ajpgi.90590.2008. PMID 19407215. 
  • Malo MS, Zhang W, Alkhoury F, et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.". Mol. Endocrinol. 18 (8): 1941-62. doi:10.1210/me.2003-0351. PMID 15143152. 
  • Rump A, Kasper G, Hayes C, et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.". Genomics 73 (1): 50-5. doi:10.1006/geno.2000.6504. PMID 11352565. 
  • Nauli AM, Zheng S, Yang Q, et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation.". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583-7. doi:10.1152/ajpgi.00482.2002. PMID 12466148. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285-90. doi:10.1152/ajpgi.00037.2005. PMID 15774940. 
  • Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.". Semin. Oncol. 29 (6 Suppl 19): 14-21. doi:10.1053/sonc.2002.37356. PMID 12577238. 
  • Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.". Pathol. Res. Pract. 203 (6): 485-7. doi:10.1016/j.prp.2007.02.003. PMID 17498884. 
  • Hinnebusch BF, Siddique A, Henderson JW, et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23-30. doi:10.1152/ajpgi.00203.2003. PMID 12919939. 
  • Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases.". J. Biol. Chem. 277 (51): 49808-14. doi:10.1074/jbc.M207394200. PMID 12372831. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Goldberg RF, Austen WG, Zhang X, et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551-6. doi:10.1073/pnas.0712140105. PMID 18292227. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220-6. doi:10.1152/ajpgi.00449.2004. PMID 15831710. 
  • Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.". EMBO J. 25 (24): 5670-82. doi:10.1038/sj.emboj.7601459. PMID 17139249. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 


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