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Aristaless-like homeobox 4
Symbols ALX4; FPP; PFM; PFM1; PFM2; KIAA1788
External IDs OMIM605420 MGI108359 HomoloGene7229 GeneCards: ALX4 Gene
RNA expression pattern
PBB GE ALX4 208330 at tn.png
More reference expression data
Species Human Mouse
Entrez 60529 11695
Ensembl ENSG00000052850 ENSMUSG00000040310
UniProt Q9H161 O35137
RefSeq (mRNA) NM_021926 NM_007442
RefSeq (protein) NP_068745 NP_031468
Location (UCSC) Chr 11:
44.24 - 44.29 Mb
Chr 2:
93.44 - 93.48 Mb
PubMed search [1] [2]

Homeobox protein aristaless-like 4 is a protein that in humans is encoded by the ALX4 gene.[1][2][3]



ALX4 has been shown to interact with Lymphoid enhancer-binding factor 1.[4]


  1. ^ Wu YQ, Badano JL, McCaskill C, Vogel H, Potocki L, Shaffer LG (Nov 2000). "Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome". Am J Hum Genet 67 (5): 1327–32. doi:10.1016/S0002-9297(07)62963-2. PMID 11017806.  
  2. ^ Bartsch O, Wuyts W, Van Hul W, Hecht JT, Meinecke P, Hogue D, Werner W, Zabel B, Hinkel GK, Powell CM, Shaffer LG, Willems PJ (Jul 1996). "Delineation of a contiguous gene syndrome with multiple exostoses, enlarged parietal foramina, craniofacial dysostosis, and mental retardation, caused by deletions in the short arm of chromosome 11". Am J Hum Genet 58 (4): 734–42. PMID 8644736.  
  3. ^ "Entrez Gene: ALX4 aristaless-like homeobox 4".  
  4. ^ Boras, Kata; Hamel Paul A (Jan. 2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". J. Biol. Chem. (United States) 277 (2): 1120–7. doi:10.1074/jbc.M109912200. ISSN 0021-9258. PMID 11696550.  

External Links

Further reading

  • Qu S, Tucker SC, Zhao Q, et al. (1999). "Physical and genetic interactions between Alx4 and Cart1.". Development 126 (2): 359–69. PMID 9847249.  
  • Wuyts W, Cleiren E, Homfray T, et al. (2001). "The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500).". J. Med. Genet. 37 (12): 916–20. PMID 11106354.  
  • Mavrogiannis LA, Antonopoulou I, Baxová A, et al. (2001). "Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects.". Nat. Genet. 27 (1): 17–8. doi:10.1038/83703. PMID 11137991.  
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.  
  • Boras K, Hamel PA (2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity.". J. Biol. Chem. 277 (2): 1120–7. doi:10.1074/jbc.M109912200. PMID 11696550.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Wakui K, Gregato G, Ballif BC, et al. (2005). "Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndrome.". Eur. J. Hum. Genet. 13 (5): 528–40. doi:10.1038/sj.ejhg.5201366. PMID 15852040.  
  • Mavrogiannis LA, Taylor IB, Davies SJ, et al. (2006). "Enlarged parietal foramina caused by mutations in the homeobox genes ALX4 and MSX2: from genotype to phenotype.". Eur. J. Hum. Genet. 14 (2): 151–8. doi:10.1038/sj.ejhg.5201526. PMID 16319823.  


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