The Full Wiki

More info on AM-906

AM-906: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

AM-906
Systematic (IUPAC) name
(6aR,9R,10aR)-3-[(Z)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Identifiers
CAS number  ?
ATC code  ?
PubChem 10089808
Chemical data
Formula C 23H34O3  
Mol. mass 358.513 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

AM-906 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.8nM at CB1 vs 9.5nM at CB2, a selectivity of almost 12x.[1]

References

  1. ^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message