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AMN082 structure.png
IUPAC name
CAS number 97075-46-2
PubChem 11698390
Molecular formula C28H30Cl2N2
Molar mass 465.4572
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

AMN082 (N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride) is a selective metabotropic glutamate receptor 7 (mGluR7) allosteric agonist.[1][2] It mimics the effect of glutamate. AMN082 is the first selective mGluR7 agonist and has expanded the potential array of research opportunities on the effects of mGluR7 in the CNS.


The two main types of glutamate receptors are ionotropic receptors and metabotropic receptors. Ionotropic receptors (iGluRs) are fast-acting ligand-gated ion channels and include AMPA, Kainate and NMDA. Metabotropic receptors are G-protein coupled receptors that mediate slower, longer lasting effects through second messenger systems and are responsible for other neuronal functions that are not typically controlled by iGluRs. mGluRs are split into 3 separate groups (Group I, Group II, Group III) based on pharmacological profile, sequence homology, and preferred signal transduction pathway. mGlur7 is a member of Group III, the least studied of the groups. The discovery of AMN082 will serve as a useful pharmacological tool to expand research on Group III mGluRs.


  1. ^ Li X, Gardner EL, Xi ZX (March 2008). "The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats". Neuropharmacology 54 (3): 542–51. doi:10.1016/j.neuropharm.2007.11.005. PMID 18155073.  
  2. ^ Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (November 2007). "Activation of the mGlu7 receptor elicits antidepressant-like effects in mice". Psychopharmacology (Berl.) 194 (4): 555–62. doi:10.1007/s00213-007-0856-2. PMID 17622518.  


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