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AMPA
AMPA.svg
IUPAC name
Identifiers
CAS number
PubChem 1221
MeSH AMPA
SMILES
InChI
InChI key UUDAMDVQRQNNHZ-UHFFFAOYAT
ChemSpider ID 1184
Properties
Molecular formula C7H10N2O4
Molar mass 186.17 g mol−1
 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.[1]

There are two broad categories of glutamate receptors: ionotropic receptors and metabotropic receptors. Ionotropic glutamate receptors are ligand gated ion channels whose agonists include AMPA, Kainate and NMDA. Metabotropic receptors are G-protein coupled receptors and are separated into individual classes. In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP).[1] AMPA receptors are non-specific cationic channels allowing the passage of Calcium, Sodium and Potassium.

References

  1. ^ a b Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed.. Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.  
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