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anoctamin 1
Symbols ANO1; FLJ10261; TMEM16A; ORAOV2; DOG1; TAOS2
External IDs OMIM610108 MGI2142149 HomoloGene75079 GeneCards: ANO1 Gene
Species Human Mouse
Entrez 55107 101772
Ensembl ENSG00000131620 ENSMUSG00000031075
UniProt Q5XXA6 Q8BHY3
RefSeq (mRNA) NM_018043 NM_178642
RefSeq (protein) NP_060513 NP_848757
Location (UCSC) Chr 11:
69.25 - 70.04 Mb
Chr 7:
151.77 - 151.92 Mb
PubMed search [1] [2]

Anoctamin 1, calcium activated chloride channel also known as ANO1 or TMEM16A is a protein which in humans is encoded by the ANO1 gene.[1][2]

The ANO1 protein functions as a calcium dependent chloride channel.[3][4]


  1. ^ "Entrez Gene: anoctamin 1, calcium activated chloride channel".  
  2. ^ Katoh M, Katoh M (June 2003). "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products". Int. J. Oncol. 22 (6): 1375–81. PMID 12739008.  
  3. ^ Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008). "TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity". Science (journal) 322 (5901): 590–4. doi:10.1126/science.1163518. PMID 18772398.  
  4. ^ Schroeder BC, Cheng T, Jan YN, Jan LY (September 2008). "Expression cloning of TMEM16A as a calcium-activated chloride channel subunit". Cell 134 (6): 1019–29. doi:10.1016/j.cell.2008.09.003. PMID 18805094.  

Further reading

  • Miwa S, Nakajima T, Murai Y, et al. (2008). "Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).". J. Gastroenterol. 43 (7): 531-7. doi:10.1007/s00535-008-2195-4. PMID 18648740.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.  
  • Liegl B, Hornick JL, Corless CL, Fletcher CD (2009). "Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes.". Am. J. Surg. Pathol. 33 (3): 437-46. doi:10.1097/PAS.0b013e318186b158. PMID 19011564.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, et al. (2009). "Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.". Am. J. Physiol. Gastrointest. Liver Physiol. 296 (6): G1370-81. doi:10.1152/ajpgi.00074.2009. PMID 19372102.  
  • Yang YD, Cho H, Koo JY, et al. (2008). "TMEM16A confers receptor-activated calcium-dependent chloride conductance.". Nature 455 (7217): 1210-5. doi:10.1038/nature07313. PMID 18724360.  
  • Katoh M, Katoh M (2004). "Identification and characterization of TMEM16E and TMEM16F genes in silico.". Int. J. Oncol. 24 (5): 1345-9. PMID 15067359.  
  • Hartzell HC, Yu K, Xiao Q, et al. (2009). "Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.". J. Physiol. (Lond.) 587 (Pt 10): 2127-39. doi:10.1113/jphysiol.2008.163709. PMID 19015192.  


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