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Aquaporin 7
Symbols AQP7; AQP7L; AQP9; AQPap; MGC149555; MGC149556
External IDs OMIM602974 MGI1314647 HomoloGene48000 GeneCards: AQP7 Gene
RNA expression pattern
PBB GE AQP7 206955 at tn.png
More reference expression data
Species Human Mouse
Entrez 364 11832
Ensembl ENSG00000165269 ENSMUSG00000028427
UniProt O14520 Q5DX24
RefSeq (mRNA) NM_001170 XM_982564
RefSeq (protein) NP_001161 XP_987658
Location (UCSC) Chr 9:
33.37 - 33.39 Mb
Chr 4:
41.22 - 41.24 Mb
PubMed search [1] [2]

Aquaporin-7 is a protein that in humans is encoded by the AQP7 gene.[1][2]

Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.[2]


See also


  1. ^ Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem 272 (33): 20782-6. PMID 9252401.  
  2. ^ a b "Entrez Gene: AQP7 aquaporin 7".  

Further reading

  • Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport.". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. PMID 9824541.  
  • Kuriyama H, Kawamoto S, Ishida N, et al. (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.". Biochem. Biophys. Res. Commun. 241 (1): 53–8. doi:10.1006/bbrc.1997.7769. PMID 9405233.  
  • Ishibashi K, Yamauchi K, Kageyama Y, et al. (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.". Biochim. Biophys. Acta 1399 (1): 62–6. PMID 9714739.  
  • Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.". Cell Tissue Res. 295 (2): 279–85. doi:10.1007/s004410051234. PMID 9931374.  
  • Kondo H, Shimomura I, Kishida K, et al. (2002). "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.". Eur. J. Biochem. 269 (7): 1814–26. doi:10.1046/j.1432-1033.2002.02821.x. PMID 11952783.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.  
  • Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers.". Biochem. Biophys. Res. Commun. 339 (3): 785–9. doi:10.1016/j.bbrc.2005.11.080. PMID 16325777.  
  • Prudente S, Flex E, Morini E, et al. (2007). "A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.". Diabetes 56 (5): 1468–74. doi:10.2337/db06-1389. PMID 17351148.  
  • Ceperuelo-Mallafré V, Miranda M, Chacón MR, et al. (2007). "Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes.". J. Clin. Endocrinol. Metab. 92 (9): 3640–5. doi:10.1210/jc.2007-0531. PMID 17566090.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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