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Aquaporin 9
Symbols AQP9; HsT17287; SSC1
External IDs OMIM602914 MGI1891066 HomoloGene41405 GeneCards: AQP9 Gene
Species Human Mouse
Entrez 366 64008
Ensembl ENSG00000103569 ENSMUSG00000032204
UniProt O43315 Q4FK77
RefSeq (mRNA) NM_020980 NM_022026
RefSeq (protein) NP_066190 NP_071309
Location (UCSC) Chr 15:
56.22 - 56.27 Mb
Chr 9:
70.91 - 70.96 Mb
PubMed search [1] [2]

Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene.[1]

The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a wide variety of noncharged solutes. AQP9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin 9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.[1]


See also


Further reading

  • Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.". Biochem. Biophys. Res. Commun. 244 (1): 268–74. doi:10.1006/bbrc.1998.8252. PMID 9514918.  
  • Tsukaguchi H, Shayakul C, Berger UV, et al. (1998). "Molecular characterization of a broad selectivity neutral solute channel.". J. Biol. Chem. 273 (38): 24737–43. doi:10.1074/jbc.273.38.24737. PMID 9733774.  
  • Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (1999). "Functional and molecular characterization of the human neutral solute channel aquaporin-9.". Am. J. Physiol. 277 (5 Pt 2): F685–96. PMID 10564231.  
  • Pastor-Soler N, Bagnis C, Sabolic I, et al. (2001). "Aquaporin 9 expression along the male reproductive tract.". Biol. Reprod. 65 (2): 384–93. doi:10.1095/biolreprod65.2.384. PMID 11466204.  
  • Damiano A, Zotta E, Goldstein J, et al. (2001). "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta.". Placenta 22 (8-9): 776–81. doi:10.1053/plac.2001.0717. PMID 11597198.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Okada S, Misaka T, Matsumoto I, et al. (2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.". FEBS Lett. 540 (1-3): 157–62. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500.  
  • Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004). "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9.". Biochem. Biophys. Res. Commun. 322 (3): 836–41. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wang S, Chen J, Beall M, et al. (2005). "Expression of aquaporin 9 in human chorioamniotic membranes and placenta.". Am. J. Obstet. Gynecol. 191 (6): 2160–7. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.  
  • Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas.". Placenta 27 (11-12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Loitto VM, Huang C, Sigal YJ, Jacobson K (2007). "Filopodia are induced by aquaporin-9 expression.". Exp. Cell Res. 313 (7): 1295–306. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.  
  • Warth A, Mittelbronn M, Hülper P, et al. (2007). "Expression of the water channel protein aquaporin-9 in malignant brain tumors.". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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