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AR-R17779
Systematic (IUPAC) name
(5S)-spiro[1,3-oxazolidine-5,8'-1-azabicyclo[2.2.2]octane]-2-one
Identifiers
CAS number 178419-47-1
ATC code  ?
PubChem 5310971
Chemical data
Formula C9H14N2O2 
Mol. mass 182.219
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal

AR-R17779 is a drug which acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] It has nootropic effects in animal studies,[3][4] but its effects do not substitute for those of nicotine.[5] It has also recently been studied as a potential novel treatment for arthritis.[6]

References

  1. ^ Mullen, G; Napier; Balestra; Decory; Hale; Macor; Mack; Loch J et al. (2000). "(-)-Spiro1-azabicyclo2.2.2octane-3,5'-oxazolidin-2'-one, a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor". Journal of medicinal chemistry 43 (22): 4045–50. doi:10.1021/jm000249r. PMID 11063601.  edit
  2. ^ Macor, J.; Mullen, G.; Verhoest, P.; Sampognaro, A.; Shepardson, B.; Mack, R. (2004). "A chiral synthesis of (-)-spiro1-azabicyclo2.2.2octane-3,5'- oxazolidin-2'-one: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist". The Journal of organic chemistry 69 (19): 6493–6495. doi:10.1021/jo049404q. PMID 15357617.  edit
  3. ^ Levin, ED; Bettegowda; Blosser; Gordon (1999). "AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats". Behavioural pharmacology 10 (6-7): 675–80. PMID 10780509.  edit
  4. ^ Van Kampen, M.; Selbach, K.; Schneider, R.; Schiegel, E.; Boess, F.; Schreiber, R. (2004). "AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors". Psychopharmacology 172 (4): 375–383. doi:10.1007/s00213-003-1668-7. PMID 14727003.  edit
  5. ^ Grottick, AJ; Trube; Corrigall; Huwyler; Malherbe; Wyler; Higgins (2000). "Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine". The Journal of pharmacology and experimental therapeutics 294 (3): 1112–9. PMID 10945867.  edit
  6. ^ Van Maanen, M.; Lebre, M.; Van Der Poll, T.; Larosa, G.; Elbaum, D.; Vervoordeldonk, M.; Tak, P. (2009). "Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice". Arthritis and rheumatism 60 (1): 114–122. doi:10.1002/art.24177. PMID 19116908.  edit
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