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AT rich interactive domain 1A (SWI-like)

PDB rendering based on 1ryu.
Available structures
Symbols ARID1A; B120; BAF250; BAF250a; BM029; C1orf4; P270; SMARCF1
External IDs OMIM603024 MGI1935147 HomoloGene21216 GeneCards: ARID1A Gene
RNA expression pattern
PBB GE ARID1A 210649 s at tn.png
PBB GE ARID1A 212152 x at tn.png
PBB GE ARID1A 218917 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8289 93760
Ensembl ENSG00000117713 n/a
UniProt O14497 n/a
RefSeq (mRNA) NM_006015 XM_992304
RefSeq (protein) NP_006006 XP_997398
Location (UCSC) Chr 1:
26.9 - 26.98 Mb
PubMed search [1] [2]

AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.[1][2][3]

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.[3]



ARID1A has been shown to interact with SMARCB1[4][5] and SMARCA4.[5][6]


  1. ^ Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (Aug 1998). "Chromosomal mapping and expression of the human B120 gene". Gene 213 (1-2): 189–93. PMID 9630625.  
  2. ^ Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (Feb 1998). "Molecular cloning and expression of a novel human cDNA containing CAG repeats". Gene 204 (1-2): 71–7. PMID 9434167.  
  3. ^ a b "Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)".  
  4. ^ Kato, Hiroyuki; Tjernberg Agneta, Zhang Wenzhu, Krutchinsky Andrew N, An Woojin, Takeuchi Tamotsu, Ohtsuki Yuji, Sugano Sumio, de Bruijn Diederik R, Chait Brian T, Roeder Robert G (Feb. 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. (United States) 277 (7): 5498–505. doi:10.1074/jbc.M108702200. ISSN 0021-9258. PMID 11734557.  
  5. ^ a b Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (Oct. 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMID 8895581.  
  6. ^ Zhao, K; Wang W, Rando O J, Xue Y, Swiderek K, Kuo A, Crabtree G R (Nov. 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell (UNITED STATES) 95 (5): 625–36. ISSN 0092-8674. PMID 9845365.  

Further reading

  • Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes.". Curr. Opin. Genet. Dev. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Wang W, Xue Y, Zhou S, et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes.". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.  
  • Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.". Embo J. 15 (19): 5370–82. PMID 8895581.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Dallas PB, Cheney IW, Liao DW, et al. (1998). "p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.". Mol. Cell. Biol. 18 (6): 3596–603. PMID 9584200.  
  • Dallas PB, Pacchione S, Wilsker D, et al. (2000). "The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity.". Mol. Cell. Biol. 20 (9): 3137–46. doi:10.1128/MCB.20.9.3137-3146.2000. PMID 10757798.  
  • Nie Z, Xue Y, Yang D, et al. (2000). "A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex.". Mol. Cell. Biol. 20 (23): 8879–88. doi:10.1128/MCB.20.23.8879-8888.2000. PMID 11073988.  
  • Takeuchi T, Nicole S, Misaki A, et al. (2001). "Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma.". Am. J. Pathol. 158 (2): 663–72. PMID 11159203.  
  • Kozmik Z, Machon O, Králová J, et al. (2001). "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex.". Genomics 73 (2): 140–8. doi:10.1006/geno.2001.6477. PMID 11318604.  
  • Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.  
  • Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.". Nature 414 (6866): 924–8. doi:10.1038/414924a. PMID 11780067.  
  • Hurlstone AF, Olave IA, Barker N, et al. (2002). "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.". Biochem. J. 364 (Pt 1): 255–64. PMID 11988099.  
  • Inoue H, Furukawa T, Giannakopoulos S, et al. (2003). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.". J. Biol. Chem. 277 (44): 41674–85. doi:10.1074/jbc.M205961200. PMID 12200431.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMID 12665591.  
  • Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.". Cell 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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