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AT rich interactive domain 3A (BRIGHT-like)
Identifiers
Symbols ARID3A; BRIGHT; DRIL1; DRIL3; E2FBP1
External IDs OMIM603265 MGI1328360 HomoloGene3827 GeneCards: ARID3A Gene
RNA expression pattern
PBB GE ARID3A 205865 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1820 13496
Ensembl ENSG00000116017 ENSMUSG00000019564
UniProt Q99856 Q3U338
RefSeq (mRNA) NM_005224 NM_007880
RefSeq (protein) NP_005215 NP_031906
Location (UCSC) Chr 19:
0.88 - 0.92 Mb
Chr 10:
79.33 - 79.36 Mb
PubMed search [1] [2]

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.[1][2]

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.[2]

Contents

Interactions

ARID3A has been shown to interact with E2F1[3] and Bruton's tyrosine kinase.[4]

References

  1. ^ Kortschak RD, Reimann H, Zimmer M, Eyre HJ, Saint R, Jenne DE (Nov 1998). "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome". Genomics 51 (2): 288–92. doi:10.1006/geno.1998.5259. PMID 9722953.  
  2. ^ a b "Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1820.  
  3. ^ Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug. 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene (ENGLAND) 17 (7): 853–65. doi:10.1038/sj.onc.1202163. ISSN 0950-9232. PMID 9780002.  
  4. ^ Nixon, Jamee C; Rajaiya Jaya B, Ayers Neil, Evetts Seth, Webb Carol F (Mar. 2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cell. Immunol. (United States) 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. ISSN 0008-8749. PMID 15203319.  

Further reading

  • Kortschak RD, Tucker PW, Saint R (2000). "ARID proteins come in from the desert.". Trends Biochem. Sci. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570.  
  • Suzuki M, Okuyama S, Okamoto S, et al. (1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.". Oncogene 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002.  
  • Peeper DS, Shvarts A, Brummelkamp T, et al. (2002). "A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.". Nat. Cell Biol. 4 (2): 148–53. doi:10.1038/ncb742. PMID 11812999.  
  • Kaiwen M (2002). "[Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway]". Kokubyo Gakkai Zasshi 69 (2): 152–61. PMID 12136662.  
  • Goebel P, Montalbano A, Ayers N, et al. (2002). "High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes.". J. Immunol. 169 (5): 2477–87. PMID 12193717.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ma K, Araki K, Ichwan SJ, et al. (2004). "E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.". Mol. Cancer Res. 1 (6): 438–44. PMID 12692263.  
  • Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T (2005). "E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies.". Cell Death Differ. 11 (7): 747–59. doi:10.1038/sj.cdd.4401412. PMID 15017387.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Nixon JC, Rajaiya JB, Ayers N, et al. (2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.". Cell. Immunol. 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319.  
  • Rajaiya J, Nixon JC, Ayers N, et al. (2006). "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.". Mol. Cell. Biol. 26 (12): 4758–68. doi:10.1128/MCB.02009-05. PMID 16738337.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Lin D, Ippolito GC, Zong RT, et al. (2007). "Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer.". Mol. Cancer 6: 23. doi:10.1186/1476-4598-6-23. PMID 17386101.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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