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AS-19 (drug): Wikis


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AS-19 (drug)
Systematic (IUPAC) name
(2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
Identifiers
CAS number  ?
ATC code  ?
PubChem 23642275
Chemical data
Formula C 18H25N3  
Mol. mass 283.411 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

AS-19 is a substance which acts as a potent agonist at the 5HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long term memory acquisition, but inhibits short term memory formation.[1][2]

References

  1. ^ Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behavioural Brain Research. 2008 Dec 16;195(1):112-9. PMID 18191236
  2. ^ Perez-García G, Meneses A. Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia. Behavioural Brain Research. 2008 Dec 16;195(1):139-46. PMID 18723050







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