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Achaete-scute complex homolog 2 (Drosophila)
Identifiers
Symbols ASCL2; ASH2; HASH2; MASH2
External IDs OMIM601886 MGI96920 HomoloGene3789 GeneCards: ASCL2 Gene
RNA expression pattern
PBB GE ASCL2 207607 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 430 17173
Ensembl ENSG00000183734 ENSMUSG00000009248
UniProt Q99929 Q3TJR9
RefSeq (mRNA) NM_005170 NM_008554
RefSeq (protein) NP_005161 NP_032580
Location (UCSC) Chr 11:
2.25 - 2.25 Mb
Chr 7:
142.78 - 142.78 Mb
PubMed search [1] [2]

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.[1]

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.[1]

Interactions

ASCL2 has been shown to interact with NCOA6[2] and RBBP5.[2]

References

  1. ^ a b "Entrez Gene: ASCL2 achaete-scute complex homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=430.  
  2. ^ a b Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. ISSN 0270-7306. PMID 12482968.  

Further reading

  • Miyamoto T, Jinno Y, Sasaki T, et al. (1996). "Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).". Cytogenet. Cell Genet. 73 (4): 312–4. doi:10.1159/000134364. PMID 8751384.  
  • Alders M, Hodges M, Hadjantonakis AK, et al. (1997). "The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.". Hum. Mol. Genet. 6 (6): 859–67. doi:10.1093/hmg/6.6.859. PMID 9175731.  
  • Miyamoto T, Jinno Y, Miura K, et al. (1998). "A SacII polymorphism in the human ASCL2 (HASH2) gene region.". J. Hum. Genet. 43 (1): 69–70. doi:10.1007/s100380050041. PMID 9610003.  
  • Onions J, Hermann S, Grundström T (2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.". Biochemistry 39 (15): 4366–74. doi:10.1021/bi992533u. PMID 10757985.  
  • Westerman BA, Poutsma A, Looijenga LH, et al. (2001). "The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.". Placenta 22 (6): 511–8. doi:10.1053/plac.2001.0695. PMID 11440538.  
  • Miyamoto T, Hasuike S, Jinno Y, et al. (2002). "The human ASCL2 gene escaping genomic imprinting and its expression pattern.". J. Assist. Reprod. Genet. 19 (5): 240–4. doi:10.1023/A:1015362903486. PMID 12099555.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goo YH, Sohn YC, Kim DH, et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMID 12482968.  
  • Jiang B, Mendelson CR (2003). "USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia.". Mol. Cell. Biol. 23 (17): 6117–28. doi:10.1128/MCB.23.17.6117-6128.2003. PMID 12917334.  
  • Koide S, Yoshida I, Tsuji A, Matsuda Y (2004). "The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2.". J. Biochem. 134 (3): 433–40. doi:10.1093/jb/mvg161. PMID 14561729.  
  • Jubb AM, Chalasani S, Frantz GD, et al. (2006). "Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.". Oncogene 25 (24): 3445–57. doi:10.1038/sj.onc.1209382. PMID 16568095.  
  • Shahib MN, Martaadisoebrata D, Kato H (2007). "Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease.". The Journal of reproductive medicine 51 (11): 892–6. PMID 17165436.  
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