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Activating transcription factor 5
Identifiers
Symbols ATF5; ATFX; FLJ34666; HMFN0395
External IDs OMIM606398 MGI2141857 HomoloGene32142 GeneCards: ATF5 Gene
RNA expression pattern
PBB GE ATF5 204998 s at tn.png
PBB GE ATF5 204999 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22809 107503
Ensembl ENSG00000169136 ENSMUSG00000038539
UniProt Q9Y2D1 Q3TVK2
RefSeq (mRNA) NM_012068 NM_030693
RefSeq (protein) NP_036200 NP_109618
Location (UCSC) Chr 19:
55.12 - 55.13 Mb
Chr 7:
44.68 - 44.68 Mb
PubMed search [1] [2]

Activating transcription factor 5, also known as ATF5, is a protein which in humans is encoded by the ATF5 gene.[1]

Contents

Function

First described by Nishizawa and Nagata,[2] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[3][4]

ATF5 transcripts and protein are expressed in a wide variety of tissues, particularly high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at the transcriptional and translational level.

See also

Interactions

ATF5 has been shown to interact with DISC1[5] and TRIB3.[6]

References

  1. ^ "Entrez Gene: ATF5 activating transcription factor 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22809.  
  2. ^ Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. PMID 10373550.  
  3. ^ Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene 273 (1): 1–11. PMID 11483355.  
  4. ^ Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–35. PMID 12192032.  
  5. ^ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. ISSN 0964-6906. PMID 12812986.  
  6. ^ Zhou, Ying; Li Lu, Liu Qiongming, Xing Guichun, Kuai Xuezhang, Sun Jing, Yin Xiushan, Wang Jian, Zhang Lingqiang, He Fuchu (May. 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. (England) 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110.  

Further reading

  • Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.". Mol. Cell. Biol. 19 (7): 5001–13. PMID 10373550.  
  • White JH, McIllhinney RA, Wise A, et al. (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMID 11087824.  
  • Peters CS, Liang X, Li S, et al. (2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase.". J. Biol. Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.". Hum. Mol. Genet. 12 (13): 1591–608. PMID 12812986.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.". Oncogene 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.  
  • Liu W, Sun M, Jiang J, et al. (2004). "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.". Biochem. Biophys. Res. Commun. 321 (4): 954–60. doi:10.1016/j.bbrc.2004.07.053. PMID 15358120.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Forgacs E, Gupta SK, Kerry JA, Semmes OJ (2005). "The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription.". J. Virol. 79 (11): 6932–9. doi:10.1128/JVI.79.11.6932-6939.2005. PMID 15890932.  
  • Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP.". Biol. Chem. 386 (9): 873–9. doi:10.1515/BC.2005.102. PMID 16164412.  
  • Angelastro JM, Canoll PD, Kuo J, et al. (2006). "Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5.". Oncogene 25 (6): 907–16. doi:10.1038/sj.onc.1209116. PMID 16170340.  
  • Wei Y, Jiang J, Sun M, et al. (2006). "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.". Biochem. Biophys. Res. Commun. 339 (2): 591–6. doi:10.1016/j.bbrc.2005.11.054. PMID 16300731.  
  • Kakiuchi C, Ishiwata M, Nanko S, et al. (2007). "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder.". Neurosci. Lett. 417 (3): 316–21. doi:10.1016/j.neulet.2007.02.054. PMID 17346882.  
  • Watatani Y, Ichikawa K, et al. (2008). "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region.". J. Biol. Chem. 283 (5): 2543–53. PMID 18055463.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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