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ATPase, Class VI, type 11B
Identifiers
Symbols ATP11B; ATPIF; ATPIR; DKFZP434J238; DKFZP434N1615; KIAA0956; MGC46576
External IDs OMIM605869 MGI1923545 HomoloGene32919 GeneCards: ATP11B Gene
RNA expression pattern
PBB GE ATP11B 212536 at tn.png
PBB GE ATP11B gnf1h02491 at tn.png
PBB GE ATP11B gnf1h02492 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23200 76295
Ensembl ENSG00000058063 ENSMUSG00000037400
UniProt Q9Y2G3 n/a
RefSeq (mRNA) NM_014616 NM_029570
RefSeq (protein) NP_055431 NP_083846
Location (UCSC) Chr 3:
183.99 - 184.12 Mb
Chr 3:
35.97 - 36.05 Mb
PubMed search [1] [2]

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.[1][2][3]

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM][3]

References

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63-70. PMID 10231032.  
  2. ^ Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Oct 2000). "Differential expression of putative transbilayer amphipath transporters". Physiol Genomics 1 (3): 139-50. PMID 11015572.  
  3. ^ a b "Entrez Gene: ATP11B ATPase, Class VI, type 11B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23200.  

Further reading

  • Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Halleck MS, Schlegel RA, Williamson PL (2002). "Reanalysis of ATP11B, a type IV P-type ATPase.". J. Biol. Chem. 277 (12): 9736–40. doi:10.1074/jbc.M200240200. PMID 11790799.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
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