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ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Symbol ATP2A2
Alt. symbols ATP2B, DAR
Entrez 488
HUGO 812
OMIM 108740
RefSeq NM_001681
UniProt P16615
Other data
EC number
Locus Chr. 12 q23-q24

ATP2A2 is an ATPase associated with Darier's disease. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.

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